"When Enola Holmes, sister to the detective Sherlock Holmes, discovers her mother has disappeared, she quickly embarks on a journey to London in search of her. But nothing can prepare her for what awaits. Because when she arrives, she finds herself involved in the kidnapping of a young marquess, fleeing murderous villains, and trying to elude her shrewd older brothers--all while attempting to piece together clues to her mother's strange disappearance....

After fourteen-year-old Enola Holmes seeks the missing Duquessa Del Campo in the seedy underbelly of nineteenth-century London, she finally reaches an understanding with her brothers Sherlock and Mycroft.